Pomalidomide-PEG1-azide 是一种 E3 连接酶配体-linker 偶联物。Pomalidomide-PEG1-azide 包含 cereblon 配体和linker，Pomalidomide-PEG1-azide 可用于设计 PROTAC BRD4 Degrader-1 。
货号:ajcx38260
CAS:2133360-04-8
分子式:C17H16N6O6
分子量：400.35
溶解度:DMSO : 62.5 mg/mL (156.11 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-PEG1-azide can be used to design a PROTAC BRD4 Degrader-1 [1].

[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.