AZD4721 (RIST4721) 是酸性 CXC 趋化因子受体 2 (CXCR2) 的有效且具有口服活性的拮抗剂。AZD4721 具有研究炎症性疾病的潜力。
货号:ajcx37372
CAS:1418112-77-2
分子式:C19H25FN4O5S2
分子量：472.55
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). AZD4721 has the potential for the research of inflammatory disease[1].

Assessment of Pharmacokinetics (PK) profile of AZD4721 (RIST4721) in rat and dog[1]. In Vivo PK Rat Dog Predicted hepatic metabolic CL (ml/min per kilogram)1.70.80 Observed CL (ml/min per kilogram)2.40.50 CLrenal (mL/min per kilogram)biliary (mL/min per kilogram)intc1.40.6 VSS (l/kg)0.190.15 T1/2 (h) (PO)1.33.7 (2.7)(8.4) F (%)4582

[1]. Gardiner P, et al. Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs. Drug Metab Dispos. 2019;47(8):865-873.