CSP1 是一种有效的、选择性的 ComD1 受体激动剂，IC50 值为 10.3 nM。CSP1 是能力刺激肽 (CSP) 的主要变体，它可以通过调节群体感应 (QS) 来调节肺炎链球菌的遗传转化。CSP1 可以作为抗菌剂。
货号:ajcx36890
CAS:172889-49-5
分子式:C103H168N30O24S
分子量：2242.69
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CSP1 is a potent and selective ComD1 receptor agonist, with an IC50 of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS). CSP1 can act as an antibacterial agent[1][2].

[1]. Yang Y, et, al. Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumonia. Biochemistry. 2018 Sep 11;57(36):5359-5369.
[2]. Johnsborg O, et, al. A hydrophobic patch in the competence-stimulating Peptide, a pneumococcal competence pheromone, is essential for specificity and biological activity. J Bacteriol. 2006 Mar; 188(5): 1744-9.