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Furanodienone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Furanodienone图片
规格:98%
分子量:230.3
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Furanodienone 是源自姜黄根茎 Rhizoma Curcumae 的主要生物活性成分之一。Furanodienone 诱导细胞凋亡 (apoptosis)。
货号:ajcx34788
CAS:24268-41-5
分子式:C15H18O2
分子量:230.3
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1].

Furanodienone (0-573.8 μM; 24 hours) exhibits IC50 values : 56.4 μM (RKO), 73.7 μM (sw480), 251.1 μM (HT-29), 412.5 μM (sw620) and 573.8 μM (LoVo) at 24 hours, while that in 48 h are 51.8 μM (RKO), 44.18 μM (sw480), 168.9 μM (HT-29), 314.2 μM (sw620) and 502.1 μM (LoVo), respectively[1].Furanodienone (0-150 μM; 24 hours) induces apoptosis and shows increase in caspase-9 and -3 activity has been observed in both cells, whereas a relative minor effect on that of caspase-8 in RKO and HT-29 cells[1].Furanodienone (0-150 μM; 24 hours) increases the apoptotic rates from 2.34±0.45% to 19.45±2.37% and 27.34±0.79%, in RKO cells at 75 and 150 μM. whereas 12.4±1.08 and 20.64±3.02% apoptosis at the concentration of 75 and 150 μM are observed in HT-29 cells compared with 2.89±0.26%[1].

[1]. Li YW, et al. Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells. Cancer Chemother Pharmacol. 2011 Nov;68(5):1315-23.