Bis-PEG6-acid 是一种 PROTAC linker，属于 PEG 类。Bis-PEG5-propionic acid 可用于合成一系列 PROTAC 分子。
货号:ajcx29192
CAS:119189-70-7
分子式:C16H30O10
分子量：382.4
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.