An active metabolite of perphenazine
货号:ajcx28528
CAS:10078-25-8
分子式:C21H26ClN3O2S
分子量：420
溶解度:DMF: 3 mg/ml,DMSO: 2 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): insol
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Perphenazine sulfoxide is an active metabolite of the typical antipsychotic perphenazine .¹It is formedviaoxidation of perphenazine. Perphenazine sulfoxide selectively binds to dopamine D₂and α₁-adrenergic receptors (α₁-ARs) over α₂-ARs (K_is= 5.9, 24, and 683 nM, respectively) in rat brain.²It increases thrombin-induced increases in phosphatidylinositol levels in isolated human platelets when used at a concentration of 5 µM.³

1.Hals, P.A., Hall, H., and Dahl, S.G.Phenothiazine drug metabolites: Dopamine D2 receptor, α1- and α2-adrenoceptor bindingEur. J. Pharmacol.125(3)373-381(1986) 2.Tharmapathy, P., Fukami, M.H., and Holmsen, H.The stimulatory effects of cationic amphiphilic drugs on human platelets treated with thrombinBiochem. Pharmacol.60(9)1267-1277(2000)