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CP 226,269
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CP 226,269图片
规格:98%
分子量:310.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A dopamine D4 receptor agonist
货号:ajcx26082
CAS:220941-93-5
分子式:C18H19FN4
分子量:310.4
溶解度:DMSO: 31 mg/mL
纯度:98%
存储:Store at -20°C
库存:现货

Background:


CP 226,269 is a dopamine D4receptor agonist.1It induces calcium flux in HEK293 cells co-expressing human dopamine D4, but not D2Lor D3, receptors and Gαqo5(EC50s = 32, >10,000, and 985 nM, respectively). CP 226,269 induces phospholipid methylation in SK-N-MC neuroblastoma cells, which endogenously express dopamine D1and D4receptors (EC50= 2.9 nM).2


1.Moreland, R.B., Nakane, M., Donnelly-Roberts, D., et al.Comparative pharmacology of human dopamine D2-like receptor stable cell lines coupled to calcium flux through Gqo5Biochem. Pharmacol.68(4)761-772(2004) 2.Sharma, A., Kramer, M.L., Wick, P.F., et al.D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophreniaMol. Psychiatry4(3)235-246(1999)