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Pyridostigmine-d3(bromide)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pyridostigmine-d3(bromide)图片
规格:98%
分子量:264.1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An internal standard for the quantification of pyridostigmine
货号:ajcx25804
CAS:N/A
分子式:C9H10D3N2O2·Br
分子量:264.1
溶解度:Water: 100 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Pyridostigmine-d3is intended for use as an internal standard for the quantification of pyridostigmine by GC- or LC-MS. Pyridostigmine is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.35 and 1 μM, respectively, for the human enzymes).1Pyridostigmine (10 µM) reduces decreases in AChE activity induced by the organophosphate pesticides diisopropyl fluorophosphate, chlorpyrifos-oxon, diazinon-oxon, paraoxon, and malaoxon in isolated bovine red blood cells.2It also reduces soman-induced membrane depolarization and decreases in AChE activity in isolated human muscle bundles in a concentration-dependent manner.3Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia and increases in sympathetic tone in mice following myocardial infarction induced by left coronary artery ligation.4Formulations containing pyridostigmine have been used in the treatment of myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.


1.Strelnik, A.D., Petukhov, A.S., Zueva, I.V., et al.Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profileBioorg. Med. Chem. Lett.26(16)4092-4094(2016) 2.Henderson, J.D., Glucksman, G., Leong, B., et al.Pyridostigmine bromide protection against acetylcholinesterase inhibition by pesticidesJ. Biochem. Mol. Toxicol.26(1)31-34(2012) 3.Maselli, R.A., Henderson, J.D., Ng, J., et al.Protection of human muscle acetylcholinesterase from soman by pyridostigmine bromideMuscle Nerve43(4)591-595(2011) 4.Durand, M.T., Becari, C., de Oliveira, M., et al.Pyridostigmine restores cardiac autonomic balance after small myocardial infarction in micePLoS One9(8)e104476(2014)