Reticulol is an isocoumarin analogue produced by certain species of Streptomyces that inhibits cAMP phosphodiesterase (IC50 = 41 μM). Reticulol was extracted from the culture broth of the strain Streptoverticillium sp. NA-4803. Recticulol (M.W. 222.2) exhibited a potent in vitro cytotoxicity against A427, a human lung tumor cell line, and B16F10, a mouse melanoma cell line. References: Lim DS, Kwak YS, Lee KH, Ko SH, Yoon WH, Lee WY, Kim CH. Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma. Chemotherapy. 2003 Sep;49(5):257-63. PubMed PMID: 14504438.

纯度：≥98%

CAS：26246-41-3