BB-Cl-Amidine hydrochloride 是肽基精氨酸脱胺酶 (PAD) 的抑制剂。
货号:ajcx13750
CAS:N/A
分子式:C26H27Cl2N5O
分子量：496.43
溶解度:DMSO: ≥ 100 mg/mL (201.44 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor. PAD[1].

Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely[1]. Animal Model: MRL/lpr mice[1].

[1]. Knight JS, et al. Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice. Ann Rheum Dis. 2015 Dec;74(12):2199-206.