GSK840(GSK’840)是一种受体相互作用蛋白激酶3(RIP3orRIPK3)抑制剂，高亲和力结合RIP3激酶结构域，IC50值为0.9nM，并抑制激酶活性，IC50值为0.3nM。
货号:ajcx13600
CAS:2361146-30-5
分子式:C21H23N3O3
分子量：365.43
溶解度:110 mg/mL in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GSK840 (GSK’840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM[1]. IC50: 0.3 nM (RIP3)[1]

参考文献:
[1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.