cRIPGBM是RIPGBM的促凋亡衍生物，是通过与受体相互作用蛋白激酶2(RIPK2)结合，诱导GBM肿瘤干细胞凋亡的选择性诱导剂，对GBM-1细胞的EC50值为68nM。
货号:ajcx13594
CAS:N/A
分子式:C26H21N2O2
分子量：393.46
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

cRIPGBM, a proapoptotic derivative of RIPGBM, a cell type-selective inducer of apoptosis in GBM cancer stem cells (CSCs) by binding to receptor-interacting protein kinase 2 (RIPK2), with an EC50 of 68 nM in GBM-1 cells[1]. RIPK2[1].

[1]. Lucki NC, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440.