R8-T198wt 是一种细胞可渗透的羧基末端 p27Kip1 肽，通过抑制 Pim-1 激酶表现出抗肿瘤活性。
货号:ajcx11220
CAS:2305815-72-7
分子式:C111H211N59O26S
分子量：2820.31
溶解度:Soluble to 2 mg/ml in 20% acetonitrile / H2O
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27^Kip1. Inhibits Pim-1 phosphorylation of p27^Kip1and Bad; induces cell cycle arrest (at G₁) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cellsin vitroandin vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.