9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) 是一种稳定的非竞争性腺苷酸环化酶 (adenylate cyclase) 抑制剂，具有细胞渗透性。
货号:ajcx38992
CAS:189639-09-6
分子式:C11H17N5O3S
分子量：299.35
溶解度:DMSO : 41.67 mg/mL (139.20 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) is a stable non-competitive adenylate cyclase inhibitor with cell permeable properties[1][2].

9-Cyclopentyladenine monomethanesulfonate (200 μM, 30 min) inhibits the activation of cAMP response element binding protein (CREB) and completely blocks neurogenesis in PC12 cells[1].9-Cyclopentyladenine monomethanesulfonate (100 μM, 30min) attenuates the effect of relaxin on mechanical activity and prevents relaxin-induced hyperpolarization thereby being involved in the regulation of relaxin on ileal smooth muscle activity in female CD1 Swiss mice[2].9-Cyclopentyladenine monomethanesulfonate (100 μM, 6 hours) promotes restoration of the keratinocyte permeability barrier by inhibiting the synthesis of cAMP in male hairless mice[3].

[1]. Ulrike Riese，et al. Militarinone A induces differentiation in PC12 cells via MAP and Akt kinase signal transduction pathways. FEBS Lett. 2004 Nov 19;577(3):455-9.
[2]. Eglantina Idrizaj，et al. Relaxin influences ileal muscular activity through a dual signaling pathway in mice. World J Gastroenterol. 2018 Feb 28;24(8):882-893.
[3]. Mitsuhiro Denda, et al. Association of cyclic adenosine monophosphate with permeability barrier homeostasis of murine skin. J Invest Dermatol. 2004 Jan;122(1):140-6.