Spirapril (SCH 33844) hydrochloride 是一种有效的血管紧张素转换酶 (ACE) 抑制剂，具有降压作用。Spirapril hydrochloride 竞争性地与 ACE 结合，阻止血管紧张素I向血管紧张素 II 的转化。Spirapril hydrochloride 是螺普利拉的一种口服活性前药，可用于高血压、充血性心力衰竭的研究。
货号:ajcx37924
CAS:94841-17-5
分子式:C22H31ClN2O5S2
分子量：503.07
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active prodrug of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1].

Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.[2]

[1]. Spirapril. Drugbank.
[2]. B Maul, et al. Alcohol consumption is controlled by angiotensin II. FASEB J