| CAS NO: | 145572-44-7 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 246.35 |
|---|---|
| Formula | C15H22N2O |
| CAS No. | 145572-44-7 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 49 mg/mL (198.9 mM) |
| Water: 49 mg/mL (198.9 mM) | |
| Ethanol: 49 mg/mL (198.9 mM) | |
| Other info | Chemical Name:
1H,5H,10H-Dipyrido(2,1-f:3',2',1'-ij)(1,6)naphthyridin-10-one,
2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, (7aS,13aR,13bR,13cS)- InChi Key: AAGFPTSOPGCENQ-JLNYLFASSA-N InChi Code: InChI=1S/C15H22N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h1,7,11-13,15H,2-6,8-10H2/t11-,12+,13+,15-/m0/s1 SMILES Code: O=C1N2[C@@](CC=C1)([H])[C@]3([H])[C@](N4CCC3)([H])[C@](CCC4)([H])C2 |
| Synonyms | (-)-Sophocarpine |
| In Vitro | In vitro activity: Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. |
|---|---|
| In Vivo | Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. LD50: Mice 63.94mg/kg (i.v.). |
| Animal model | Mice |
| Formulation & Dosage | 50 mg/kg |
| References | Int Immunopharmacol. 2008 Dec 20;8(13-14):1767-72; Phytother Res. 2002 Mar;16(2):154-6; Biol Pharm Bull. 2008 Apr;31(4):627-32. |
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