ZL0590 是一种有效的，具有口服活性 BRD4 BD1 选择性抑制剂，对人 BRD4 BD1的 IC50 为 90 nM。ZL0590 具有显著的抗炎活性。
货号:ajcx37792
CAS:2230496-99-6
分子式:C23H27F3N4O4S
分子量：512.55
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ZL0590 is a potent, orally active BRD4 BD1-selective inhibitor with an IC50 of 90 nM for human BRD4 BD1. ZL0590 exhibits significant anti-inflammatory activities[1].

[1]. Liu Z, et al. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. J Med Chem. 2022;65(3):2388-2408.