| CAS NO: | 478-43-3 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| Molecular Weight (MW) | 284.22 |
|---|---|
| Formula | C15H8O6 |
| CAS No. | 478-43-3 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: <1 mg/mL |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: 4,5-Dihydroxyanthraquinone-2-carboxylic acid InChi Key: FCDLCPWAQCPTKC-UHFFFAOYSA-N InChi Code: InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21) SMILES Code: O=C(C1=C2C=CC=C1O)C3=C(O)C=C(C(O)=O)C=C3C2=O |
| Synonyms | Rhein, Monorhein, NSC-38629, NSC38629, NSC 38629, Rheinic Acid |
| In Vitro | In vitro activity: Rhein at 35 μM can effectively inhibit the synthesis of IL-1β on human osteoarthritis synovium, as well as the action of this cytokine at the cartilage level, by reducing the number of chondrocyte IL-1R and inhibiting IL-1β induced NO production in chondrocytes and cartilage. Rhein also induces apoptosis in human promyelocytic leukemia cells (HL-60), characterized by caspase activation, poly(ADP)ribose polymerase (PARP) cleavage, and DNA fragmentation. |
|---|---|
| In Vivo | Rhein is also effective in ameliorating diabetic renal pathological changes and attenuating hyperlipidemia in db/db mice with diabetic nephropathy with decreased transforming growth factor-beta1 (TGF-beta1) and fibronectin immunohistochemistry expression in renal tissue and reduced cholesterol (Chol), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and ApoE in plasma. |
| Animal model | Mice |
| Formulation & Dosage | |
| References | J Rheumatol. 1998 Apr;25(4):753-62; Arch Biochem Biophys. 2003 Oct 15;418(2):99-107; Planta Med. 2010 Jan;76(1):27-33. |
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