(S)-Sunvozertinib ((S)-DZD9008) 是 Sunvozertinib 的 S-对映体，对 EGFR 外显子 20 NPH 和 ASV 插入、EGFR L858R/T790M 突变和 Her2 外显子 20 YVMA 插入具有抑制活性 (IC50 分别为 51.2 nM、51.9 nM、1 nM 和 21.2 nM)。(S)-Sunvozertinib 也抑制 BTK。
货号:ajcx36382
CAS:2370013-49-1
分子式:C29H35ClFN7O3
分子量：584.08
溶解度:DMSO : 50 mg/mL (85.60 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(S)-Sunvozertinib ((S)-DZD9008), the S-enantiomer of Sunvozertinib, shows inhibitory activity against EGFR exon 20 NPH and ASV insertions, EGFR L858R/T790M mutation and Her2 exon20 YVMA insertion (IC50=51.2 nM, 51.9 nM, 1 nM, and 21.2 nM, respectively). (S)-Sunvozertinib also inhibits BTK[1].

(S)-Sunvozertinib shows proliferation inhibition of Ba/F3 EGFR NPH ins (GI50=139.7 nM), Ba/F3 FGFR ASV ins (155.7 nM), NCI-HI975 EGFRL858R/T790M (24.4), Her2 YVMA ins (827 nM) and WT EGFR (84.8 nM)[1].(S)-Sunvozertinib shows proliferation inhibition of BTK WT cells (OCI-LY-10, TMD-8, Ri-1and DB, with GI50 ranging from 13.7-48 nM)[1].

[1]. Zhengtao LI, et al. Erbb/btk inhibitors. WO2019149164A1.