BPK-21 是一种活性丙烯酰胺，通过阻断 ERCC3 功能来抑制 T 细胞活化。BPK-21 特异性靶向解旋酶 ERCC3 中的 C342。
货号:ajcx35822
CAS:2305052-77-9
分子式:C23H16Cl2F3NO2
分子量：466.28
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BPK-21, an active acrylamide, suppresses T cell activation through blockade of ERCC3 function. BPK-21 specifically targets C342 in the helicase ERCC3[1].

BPK-21 (20 μM) significantly impairs T cellactivation[1]. BPK-21 likely suppresses T cell activation through blockadeof ERCC3 function, which may in turn act downstream or sepa-rately from pathways involved in NFAT and NF-kB activation[1].

[1]. Ekaterina V Vinogradova, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29.