(rac)-PF-998425 是一种有效、选择性的非甾体雄激素受体 (AR) 拮抗剂。(rac)-PF-998425 在 AR 结合和细胞分析中的 IC50 值分别为 26 和 90 nM。(rac)-PF-998425 具有用于研究雄激素性脱发的潜力。
货号:ajcx35394
CAS:1076225-26-7
分子式:C14H14F3NO
分子量：269.26
溶解度:DMSO : 100 mg/mL (371.39 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(rac)-PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist. (rac)-PF-998425 has IC50 values of 26 and 90 nM in the AR binding and cellular assays, respectively. (rac)-PF-998425 has the potential for the research of the androgenetic alopecia[1].

[1]. Li JJ, et al. Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J Med Chem. 2008;51(21):7010-7014.