RAD51-IN-1 是 B02 的衍生物，是 RAD51 的有效抑制剂。 RAD51-IN-1 可用于癌症研究。
货号:ajcx35144
CAS:2101739-18-6
分子式:C22H16ClN3O
分子量：373.83
溶解度:DMSO : 62.5 mg/mL (167.19 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RAD51-IN-1, a derivative of B02, is a potent inhibitor of RAD51. RAD51-IN-1 can be used for cancer research[1].

RAD51 is a vital component of the homologous recombination DNA repair pathway and is overexpressed in drug-resistant cancers, including aggressive triple-negative breast cancer (TNBC)[1].RAD51-IN-1 (10 μM) decreases the ratio of RAD51 positive cells/cH2AX positive cells in MDA-MB-231 cell exposure to 6 Gy irradiation[1].RAD51-IN-1 (10 μM) significantly inhibits DNA damage induced RAD51 foci formation with 6 Gy irradiation[1].

[1]. Ambber Ward, et al. Quinazolinone derivatives as inhibitors of homologous recombinase RAD51. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100.