Nequinate 是一种喹啉化合物，抗球虫试剂 (anticoccidial agent)，对抗盲肠球虫 (Eimeria tenella) 感染。Nequinate 抑制黄嘌呤氧化还原酶 (XOD) 活性。
货号:ajcx35022
CAS:13997-19-8
分子式:C22H23NO4
分子量：365.42
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections[1]. Nequinate inhibits xanthine oxidoreductase (XOD) activity[2].

Xanthine oxidase (XOD) is a successful and safe drug target for lowering lower serum urate (sUA) levels , it plays an important role in the catabolism of purineNequinate shows an inhibition of 12.0% to inhibit XOD activities[2].

[1]. D K McLoughlin, et al.Efficacy of Nequinate Against Thirteen Strains of Eimeria Tenella and the Development of a Nequinate-Resistant Strain.Avian Dis. Oct-Dec 1973;17(4):717-21.
[2]. Yanfen Niu, et al. Old Drug, New Indication: Olsalazine Sodium Reduced Serum Uric Acid Levels in Mice via Inhibiting Xanthine Oxidoreductase Activity. J Pharmacol Sci. 2017 Nov;135(3):114-120.