EG1 是一种特异性 Pax2 抑制剂，直接结合 Pax2 的配对结构域 (Kd=1.35-1.5 μM) 并抑制 Pax2-DNA 相互作用。EG1 可以抑制胚胎肾脏发育，此过程直接依赖于Pax2活性。
货号:ajcx34724
CAS:693241-54-2
分子式:C22H18N2O5
分子量：390.39
溶解度:DMSO : 83.33 mg/mL (213.45 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

EG1, a specific Pax2 inhibitor, directly binds the paired domain of Pax2 (Kd=1.35-1.5 μM) and inhibits Pax2-DNA interactions. EG1 can inhibit embryonic kidney development, a process directly dependent on Pax2 activity[1].

EG1 (0-12.5 μM; 48 hours) decreases viability in Pax2 positive renal cancer cell lines[1].EG1 (0-500 μM) is capable of inhibiting Pax2 mediated expression of EGFP without significant effects on Pax2 protein levels[1].

[1]. Grimley E, et al. Inhibition of Pax2 Transcription Activation with a Small Molecule that Targets the DNA Binding Domain. ACS Chem Biol. 2017;12(3):724-734.