SCH32615是一种脑啡肽酶(enkephalinase，负责内源性脑啡肽降解的酶)的抑制剂。SCH32615可以增强小鼠手术和妊娠引起的镇痛作用。
货号:ajcx31812
CAS:83861-02-3
分子式:C21H24N2O5
分子量：384.43
溶解度:DMSO: 125 mg/mL (325.16 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SCH 32615 is an enkephalinase (the enzymes responsible for the degradation of endogenous enkephalins) inhibitor. SCH 32615 can enhance surgery- and pregnancy-induced analgesia in mice[1][2].

SCH 32615 blocks the degradation of Met5-enkephalin by isolated enkephalinase, with the Ki of 19.5 nM[3].

SCH 32615 (150 mg/kg; s.c.) enhances surgery activated endogenous analgesia in mice[1].

[1]. Jayaram A, et, al. An enkephalinase inhibitor, SCH 32615, augments analgesia induced by surgery in mice. Anesthesiology. 1995 May;82(5):1283-7. [2]. Jayaram A, et, al. SCH 32615, an enkephalinase inhibitor, enhances pregnancy-induced analgesia in mice. Anesth Analg. 1995 May;80(5):944-8. [3]. Chipkin RE, et, al. Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic. J Pharmacol Exp Ther. 1988 Jun;245(3):829-38.