Silversulfadiazine(AgSD)是一种磺胺类抗生素，通磺胺部分(SD-SDZ)对细菌(bacterial)生长产生双重抑制作用，阻止细菌叶酸吸收和随后的DNA合成(DNAsynthesis)。Silversulfadiazine释放的银结合并破坏DNA结构，阻止细菌DNA复制。
货号:ajcx31468
CAS:22199-08-2
分子式:C10H9AgN4O2S
分子量：357.14
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Silver sulfadiazine (AgSD), a sulfonamide antibiotic, effects a dual inhibitory action on bacterial growth by its sulfa moiety (SD-SDZ) that prevents bacterial folate absorption and subsequent DNA synthesis. The silver that is released from Silver sulfadiazine binds and disrupts the DNA structure, precluding bacterial DNA replication[1].

Silver sulfadiazine (AgSD) is a topical antibiotic used to the research of bacterial infection in burns[2].

[1]. Strydom SJ, et al. Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity. Nanomedicine. 2013;9(1):85-93. [2]. Munhoz DR, et al. Alginate films functionalized with silver sulfadiazine-loaded [Mg-Al] layered double hydroxide as antimicrobial wound dressing. Int J Biol Macromol. 2019;141:504-510.