Ponicidin(RubescensineB)是源于冬凌草的二萜，具有免疫调节、抗炎、抗病毒和抗癌作用。Ponicidin(RubescensineB)可诱导胃癌细胞凋亡(apoptosis)，降低JAK2和STAT3的磷酸化水平，单对其蛋白水平无作用。
货号:ajcx31332
CAS:52617-37-5
分子式:C20H26O6
分子量：362.42
溶解度:DMSO: 250 mg/mL (689.81 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3[1].

[1]. Liu YF, et al. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. Int J Mol Sci. 2015 Jan 12;16(1):1576-89.