An internal standard for the quantification of 5-hydroxy indole-3-acetic acid
货号:ajcx28518
CAS:2748469-82-9
分子式:C10H3D6NO3
分子量：197.2
溶解度:DMSO: soluble,Ethyl Acetate: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

5-hydroxy Indole-3-acetic acid-d₆(5-HIAA-d₆) is intended for use as an internal standard for the quantification of 5-HIAA by GC- or LC-MS. 5-HIAA is a metabolite of the monoamine neurotransmitter serotonin .¹It is formed from serotoninviaa 5-hydroxy indole-3-acetaldehyde intermediate by aldehyde dehydrogenase. 5-HIAA has been used as a biomarker for the detection of neuroendocrine tumors. Brain levels of 5-HIAA are decreased in patients with severe Alzheimer's disease.²

1.Corcuff, J.-B., Chardon, L., El Hajji Ridah, I., et al.Urinary sampling for 5HIAA and metanephrines determination: Revisiting the recommendationsEndocr. Connect.6(6)R87-R98(2017) 2.Vermeiren , Y., Van Dam, D., Aerts, T., et al.Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer's diseaseNeurobiol. Aging35(12)2691-2700(2014)