AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable
货号:ajcx27686
CAS:N/A
分子式:C109H181N25O35
分子量：2401.75
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable.

Wang et al (2015) PKA-type I selective constrained peptide disruptors of AKAP complexes. ACS Chem.Biol. 10 1502 PMID:25765284