BMS 566419 是一种基于吖啶酮的肌苷 5'-单磷酸脱氢酶 (IMPDH) 抑制剂。
货号:ajcx27076
CAS:566161-24-8
分子式:C28H30FN5O2
分子量：487.57
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.

Watterson et al (2007) Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J.Med.Chem. 50 3730 PMID:17585753