An internal standard for the quantification of norfluoxetine
货号:ajcx25668
CAS:1185132-92-6
分子式:C16H11D5F3NO·HCl
分子量：336.8
溶解度:Chloroform: slightly soluble,DMSO: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Norfluoxetine-d₅is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine.¹It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A.²Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (K_i= 44.7 nM) and isolated human platelets (IC₅₀= ~15 nM).¹It has been found in the tissues of fish exposed to wastewater effluent.³

1.Wong, D.T., Bymaster, F.P., Reid, L.R., et al.Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brainNeuropsychopharmacology8(4)337-344(1993) 2.Hiemke, C., and HÄrtter, S.Pharmacokinetics of selective serotonin reuptake inhibitorsPharmacol. Ther.85(1)11-28(2000) 3.Brooks, B.W., Chambliss, C.K., Stanley, J.K., et al.Determination of select antidepressants in fish from an effluent-dominated streamEnviron. Toxicol. Chem.24(2)464-469(2005)