An internal standard for the quantification of metaxalone
货号:ajcx24820
CAS:1189944-95-3
分子式:C12H9D6NO3
分子量：227.3
溶解度:Acetonitrile: Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Metaxalone-d₆is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant.^1,2It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cellsin vitrowhen used at concentrations ranging from 1 to 100 µM.²Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E₂in RAW 264.7 cells. Formulations containing metaxalone have been used in the treatment of lower back pain.

1.Chou, R., Peterson, K., and Helfand, M.Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: A systematic reviewJ. Pain Symptom Manage.28(2)140-175(2004) 2.Yamaguchi, M., and Levy, R.M.Metaxalone suppresses production of inflammatory cytokines associated with painful conditions in mouse macrophages RAW264.7 cells in vitro: Synergistic effect with β-caryophylleneCurr. Mol. Med.20(8)643-652(2020)