A P2X7 receptor antagonist
货号:ajcx24496
CAS:N/A
分子式:C13H7Cl3N4O
分子量：341.6
溶解度:DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml,DMSO: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ITH15004 is a non-nucleotide antagonist of the purinergic P2X₇receptor (IC₅₀= 9 µM in HEK293 cells expressing the human receptor).¹It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X₇receptor when used at a concentration of 100 µM. ITH15004 (1 µM) decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages. It has high permeability in a parallel artificial membrane permeability assay (PAMPA).

1.Calzaferri, F., Narros-FernÁndez, P., de Pascual, R., et al.Synthesis and pharmacological evaluation of novel non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammationJ. Med. Chem.64(4)2272-2290(2021)