A gut-restrictive antibiotic
货号:ajcx24212
CAS:N/A
分子式:C16H8Cl2F3N3O2S
分子量：434.2
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

HSGN-218 is a gut-restrictive antibiotic.¹It is active againstC. difficile(MIC = 0.007 µg/ml) and clinical isolates ofC. difficile(MICs = 0.003-0.03 µg/ml) and is not cytotoxic to Caco-2 cells when used at concentrations ranging from 4 to 64 µg/ml. HSGN-218 (50 mg/kg) increases survival and protects mice fromC. difficilerecurrence in mouse models ofC. difficileinfection.

1.Naclerio, G.A., Abutaleb, N.S., Li, D., et al.Ultrapotent inhibitor of Clostridioides difficile growth, which suppresses recurrence in vivoJ. Med. Chem.63(20)11934-11944(2020)