A long-chain atypical ceramide
货号:ajcx21878
CAS:1246298-56-5
分子式:C34H67NO2
分子量：521.9
溶解度:DMF: >20 mg/ml,DMSO: >20 mg/ml,Ethanol: >30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml,PBS (pH 7.2):<50μg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

C16 1-Deoxyceramide (m18:1/16:0) is a long-chain atypical ceramide containing a 1-deoxysphingosine (m18:1(4E)) backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.^1,2C16 1-Deoxyceramide (m18:1/16:0) has been found in RAW 264.7 cells.³

1.Steiner, R., Saied, E.M., Othman, A., et al.Elucidating the chemical structure of native 1-deoxysphingosineJ. Lipid Res.57(7)1194-1203(2016) 2.Alecu, I., Othman, A., Penno, A., et al.Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathwayJ. Lipid Res.58(1)60-71(2017) 3.JimÉnez-Rojo, N., Sot, J., Busto, J.V., et al.Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cellsBiophys. J.107(12)2850-2859(2014)