(±)-Thalidomide-d4 是氘标记的 Thalidomide。
货号:ajcx20378
CAS:1219177-18-0
分子式:C13H6D4N2O4
分子量：262.3
溶解度:DMF: 12 mg/ml,DMSO: 12 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.11 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(±)-Thalidomide-d4 is intended for use as an internal standard for the quantification of (±)-thalidomide by GC- or LC-MS. (±)-Thalidomide is an immunomodulatory and antiproliferative compound that interacts directly with the protein CRBN (IC50 = 8.5 nM), a ubiquitously-expressed E3 ligase, and CRBN-DDB1 complexes.1,2

|1. Ito, T., Ando, H., Suzuki, T., et al. Identification of a primary target of thalidomide teratogenicity. Science 327(5971), 1345-1350 (2010).|2. Lopez-Girona, A., Mendy, D., Miller, K., et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia 26(11), 2326-2335 (2012).