C31H53N9O6.XCF3COOH
货号:ajcx19634
CAS:N/A
分子式:C31H53N9O6.XCF3COOH
分子量：647.8
溶解度:DMF: 5mg/mL,DMSO: 10mg/mL,Ethanol: 0.5mg/mL,PBS (pH 7.2): 3mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TFLLR-NH2 is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that induces calcium mobilization in isolated rat dorsal root ganglion neurons (EC50 = 1.9 μM).1 In vivo, TFLLR-NH2 (3 μmol/kg) stimulates plasma extravasation in the bladder, esophagus, stomach, intestine, and pancreas in wild-type, but not PAR1-/-, mice. It also reduces carrageenan-induced hyperalgesia in rats.2

参考文献
1. de Garvilla, L., Vergnolle, N., Young, S.H., et al. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br. J. Pharmacol. 133(7), 975-987 (2001).
2. Kawabata, A., Kawao, N., Kuroda, R., et al. The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats. Peptides 23(6), 1181-1183 (2002).