MS1943 是一种一流的，具有口服生物活性的 EZH2 选择性降解剂，其IC50 为 120 nM。MS1943 显著降低了许多三阴性乳腺癌和其他癌及非癌细胞系中的EZH2蛋白水平。MS1943 有效地阻止了多个三阴性乳腺癌和其他癌细胞系的增殖。
货号:ajcx16574
CAS:2225938-17-8
分子式:C42H54N8O3
分子量：718.93
溶解度:DMSO: 125 mg/mL (173.87 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines. MS1943 effectively blocks proliferation of multiple TNBC and other cancer cell lines[1].

[1]. Ma A, et al. Discovery of a first-in-class EZH2 selective degrader.Nat Chem Biol. 2020 Feb;16(2):214-222.