E3ligaseLigand8hydrochloride是是用于PROTAC技术，可连接到E3连接酶的，BET的一个配体，其在RS4;11和MOLM-13细胞中的IC50值分别为0.98nM和13.7nM。
货号:ajcx13598
CAS:N/A
分子式:C17H22ClN3O3
分子量：351.83
溶解度:DMSO: 130 mg/mL (369.50 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

E3 ligase Ligand 8 hydrochloride (compound 24) is a Ligand of BET for E3 Ligase used in PROTAC, with IC50 values of 0.98 nM and 13.7 nM in RS4;11 and MOLM-13 cells, respectively[1]. E3 ligase[1].

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.