RUVBL1/2 ATPase-IN-1 (compound 18) 是一种有效且选择性的 RUVBL1/2 ATPase 抑制剂，IC50 值为 6.0 和 7.7 μM，分别。RUVBL1 和 RUVBL2 是高度保守的 AAA ATP 酶 (与各种细胞活动相关的 ATP 酶)，与癌症的进展高度相关。RUVBL1/2 ATPase-IN-1 具有研究癌症疾病的潜力。
货号:ajcx37616
CAS:423128-55-6
分子式:C28H28F3N5O
分子量：507.55
溶解度:DMSO : 10 mg/mL (19.70 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RUVBL1/2 ATPase-IN-1 (compound 18) is a potent and selective inhibitor of RUVBL1/2 ATPase with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1 and RUVBL2 are highly conserved AAA ATPases (ATPases Associated with various cellular Activities) and highly relevant to the progression of cancer. RUVBL1/2 ATPase-IN-1 has the potential for the research of cancer diseases[1].

[1]. Zhang G, et al. Discovery of small-molecule inhibitors of RUVBL1/2 ATPase. Bioorg Med Chem. 2022;62:116726.