规格: | 98% |
分子量: | 622.75 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
Background:
Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway[1][2].
Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner[1].Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells[2].Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM[2].Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis)[2].Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells[2].
Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM[1].
[1]. MartÍnez JA, et al. Calcium antagonist properties of the bisbenzylisoquinoline alkaloid cycleanine. Fundam Clin Pharmacol. 1998;12(2):182-7.
[2]. Uche FI, et al. Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytother Res. 2016 Sep;30(9):1533-9.