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VII-31
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VII-31图片
规格:98%
分子量:427.51
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
VII-31是NEDDylation通路激活剂,可在体内外抑制肿瘤。VII-31还诱导凋亡(apoptosis)。
货号:ajcx31650
CAS:2305757-96-2
分子式:C23H25NO5S
分子量:427.51
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

VII-31 is a potent NEDDylation pathway activator to inhibit the tumor progression in vitro and in vivo. VII-31 induces apoptosis via intrinsic and extrinsic pathways[1].

VII-31 (100 nM, 200 nM; 48 hours) inhibits the cell viability of gastric cell line MGC803 with an IC50 of 0.09±0.01 μM. VII-31 also inhibits the cell viability of MCF-7 and PC-3 with IC50s of 0.10±0.006 and 1.15±0.28μM , respectively[1].VII-31 (50-150 nM; 24 hours) arrests MGC803 cells cycle in G2/M phase[1].VII-31 (50-150 nM; 48 hours) induces apoptosis via intrinsic and extrinsic pathways[1].VII-31 (50-150 nM; 24 hours) activates NEDDylation in MGC803 cells[1].VII-31 (50-150 nM; 48 hours) up-regulates pro-apoptotic proteins FADD, Fasl, PIDD, Bax, Bad; while down-regulates anti-apoptotic proteins Bcl-xL, Bcl-2, XIAP, c-IAP1[1]. Cell Viability Assay[1] Cell Line: Gastric cancer MGC803 cells

VII-31 inhibits the tumor progression in vivo, while showing no obvious toxicity to mice[1]. Animal Model: Mice bearing MGC803 xenograft tumors[1]

[1]. Dong-Jun Fu, et al. Discovery of Novel Tertiary Amide Derivatives as NEDDylation Pathway Activators to Inhibit the Tumor Progression in Vitro and in Vivo. Eur J Med Chem. 2020 Apr 15;192:112153.