6H05TFA是突变型原癌基因K-ras(G12C)选择性变构抑制剂。
货号:ajcx30064
CAS:2061344-88-3
分子式:C22H31ClF3N3O4S3
分子量：590.14
溶解度:DMSO: ≥ 51 mg/mL (86.42 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

6H05 TFA is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value:Target: K-Ras G12C6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].

[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51. [2]. Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34(6):1242-85.