2,2,2-Trichloroethanol是镇静催眠药水合氯醛的活性形式，是非经典的K2P通道TREK-1和TRAAK的激动剂。
货号:ajcx29910
CAS:115-20-8
分子式:C2H3Cl3O
分子量：149.4
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1].

2,2,2-trichloroethanol activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery[1].

[1]. Nikhil K Parelkar , et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332(3):803-10.