您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Deacetylanisomycin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Deacetylanisomycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Deacetylanisomycin图片
规格:98%
分子量:223.3
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
脱乙酰茴香霉素是一种有效的植物生长调节剂,是茴香霉素的无活性衍生物。
货号:ajcx28556
CAS:27958-06-1
分子式:C12H17NO3
分子量:223.3
溶解度:Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Deacetylanisomycin is a derivative of the protein and DNA synthesis inhibitor anisomycin with antimalarial and anticancer activity.1,2It inhibits the growth of theP. falciparumstrains K1 and T9-96in vitro(IC50s = 40.29 and 33.57 μM, respectively).1Deacetylanisomycin is cytotoxic to LU99 lung carcinoma and MCF-7 breast cancer cells (IC50s = 23 and 34 μM, respectively). It has been used as a negative control for assessment of protein synthesis inhibitor activity in molluscan neurons.3

1.Ekong, R.M., Kirby, G.C., Patel, G., et al.Comparison of the in vitro activities of quassinoids with activity against Plasmodium falciparum, anisomycin and some other inhibitors of eukaryotic protein synthesisBiochem. Pharmacol.40(2)297-301(1990) 2.Hosoya, Y., Kameyama, T., Naganawa, H., et al.Anisomycin and new congeners active against human tumor cell linesJ. Antibiot. (Tokyo)46(8)1300-1302(1993) 3.Alkon, D.L., Bank, B., Naito, S., et al.Inhibition of protein synthesis prolongs Ca2+-mediated reduction of K+ currents in molluscan neuronsProc. Natl. Acad. Sci. USA84(19)6948-6952(1987)