ER 817692 是一种具有口服活性的高选择性前列腺素 E2 (PGE2) EP4 受体拮抗剂，对人 EP4 受体的 EC50 为 70 nM。
货号:ajcx28118
CAS:1155773-15-1
分子式:C30H39N3O3
分子量：489.65
溶解度:ethanol|2.45|5withgentlewarming|DMSO|0.98|2withgentlewarming|
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent EP4 receptor antagonist (IC50 = 59 nM). Suppresses EP4-mediated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells. Inhibits Th1 and Th17 cytokine production, suppresses collagen- and GPI-induced arthritis in mice. Attenuates CFA-induced inflammatory pain in rats. Analgesic. Orally bioavailable.