Potent NUDT5 inhibitor
货号:ajcx27662
CAS:N/A
分子式:C20H20Cl2N8O3.HCl
分子量：527.79
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent nudix hydrolase 5 (NUDT5) inhibitor (IC50 = 29 nM). Displays >650-fold selectivity for NUDT5 over MTH1. Inhibits ATP synthesis, chromatin remodeling, gene expression and proliferation in progestin-treated breast cancer cells in vitro.

Page et al (2018) Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nat.Commun. 9 250 PMID:29343827