| 规格: | 98% |
| 分子量: | 389.51 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
Background:
TRPV1 positive allosteric modulator. Potentiates vanilloid and proton activation of TRPV1 channels. Exhibits analgesic effects in combination with capsaicin in rats. Also prolongs capsaicin-induced hypothermia in mice.
Kaszas et al (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J.Pharmacol.Exp.Ther. 340 152 PMID:22005042 |Lebovitz et al (2012) Positive allosteric modulation of TRPV1 as a novel analgesic mechanism. Mol.Pain 8 PMID:22998799 |Roh et al (2008) Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1). Bioorg.Med.Chem. 16 9349 PMID:18809334
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