Background:

Emeguisin A is a depsidone fungal metabolite originally isolated fromE. unguis.¹It is active against the bacteriaS. aureusand methicillin-resistantS. aureus(MRSA; MIC = 0.5 µg/ml for both), the fungusC. neoformans(MIC = 0.5 µg/ml), and the protozoanP. falciparum(IC₅₀= 2.2 µM).²

1.Kawahara, N., Nozawa, K., Nakajima, S., et al.Isolation and structures of novel fungal depsidones, emeguisins A, B, and C, from Emericella unguisJ. Chem. Soc., Perkin Trans. 12611-2614(1988) 2.Klaiklay, S., Rukachaisirikul, V., Aungphao, W., et al.Depsidone and phthalide derivatives from the soil-derived fungus Aspergillus unguis PSU-RSPG199Tetrahedron Lett.57(39)4348-4351(2016)