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Finasteride-d9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Finasteride-d9图片
规格:98%
分子量:381.6
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
非那雄胺-d9 是氘标记的非那雄胺。 Finasteride (MK-906) 是一种有效的竞争性 5α-还原酶抑制剂,对 II 型 5α-还原酶的 IC50 为 4.2 nM。非那雄胺对 II 型 5α-还原酶的亲和力比对 I 型酶的亲和力高约 100 倍。非那雄胺可用于良性前列腺增生(BPH)和雄激素性脱发的研究。
货号:ajcx22492
CAS:1131342-85-2
分子式:C23H27D9N2O2
分子量:381.6
溶解度:Chloroform: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Finasteride-d9is intended for use as an internal standard for the quantification of finasteride by GC- or LC-MS. Finasteride is a 4-azasteroid competitive inhibitor of 5α-reductase type II (IC50= 4.2 nM) and a derivative of testosterone.1It is 100-fold selective for 5α-reductase type II over type I. Finasteride (10 µM) does not affect the growth of androgen-refractory PC3 prostate cancer cells but increases the protein levels of Nrf2 and heme oxygenase-1 (HO-1).2It decreases prostatic diameter and volume, as well as dihydrotestosterone, but not testosterone, serum levels in dogs with spontaneous benign prostatic hypertrophy when administered at doses of 0.1 and 0.5 mg/kg.3Finasteride reduces testosterone-induced type I procollagen and TGF-β1 protein levels in cultured human scalp dermal fibroblasts in a model of androgenic alopecia when applied at a concentration of 0.1 μM.4Formulations containing finasteride have been used in the treatment of benign prostatic hyperplasia and androgenic alopecia in men.


1.Flores, E., Bratoeff, E., Cabeza, M., et al.Steroid 5α-reductase inhibitorsMini Rev. Med. Chem.3(3)225-237(2003) 2.Yun, D.-K., Lee, J., and Keum, Y.-S.Finasteride increases the expression of hemoxygenase-1 (HO-1) and NF-E2-related factor-2 (Nrf2) proteins in PC-3 cells: Implication of finasteride-mediated high-grade prostate tumor occurenceBiomol. Ther. (Seoul)21(1)49-53(2013) 3.Sirinarumitr, K., Johnston, S.D., Kustritz, M.V.R., et al.Effects of finasteride on size of the prostate gland and semen quality in dogs with benign prostatic hypertrophyJ. Am. Vet. Med. Assoc.218(8)1275-1280(2001) 4.Yoo, H.G., Kim, J.S., Lee, S.R., et al.Perifollicular fibrosis: Pathogenetic role in androgenetic alopeciaBiol. Pharm. Bull.29(6)1246-1250(2006)